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TMP-153

CAS No. 128831-46-9

TMP-153 ( TMP153 )

产品货号. M11175 CAS No. 128831-46-9

TMP-153 是一种有效的酰基辅酶A:胆固醇酰基转移酶 (ACAT) 抑制剂,对多种动物的肝脏和肠道 ACAT 的 IC50 为 5-10 nM。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥2822 有现货
5MG ¥4674 有现货
10MG ¥6774 有现货
25MG ¥9858 有现货
50MG ¥12834 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    TMP-153
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    TMP-153 是一种有效的酰基辅酶A:胆固醇酰基转移酶 (ACAT) 抑制剂,对多种动物的肝脏和肠道 ACAT 的 IC50 为 5-10 nM。
  • 产品描述
    TMP-153 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor with IC50 of 5-10 nM for the hepatic and intestinal ACAT from various animals; inhibits cholesterol esterification both in human colonic adenocarcinoma cells, LS180, and in human hepatoma cells, HepG2 (IC50 = 150 nM and 330 nM, respectively); inhibits cholesterol absorption and lowers plasma cholesterol in rats and hamsters.Hypercholesterolemia Discontinued.
  • 体外实验
    ——
  • 体内实验
    ——
  • 同义词
    TMP153
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Other Targets
  • 研究领域
    Cardiovascular Disease
  • 适应症
    Hypercholesterolemia

化学信息

  • CAS Number
    128831-46-9
  • 分子量
    437.9
  • 分子式
    C24H18ClF2N3O
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    CC1=CC2=C(C(=CN=C2C=C1C)NC(=O)NC3=C(C=C(C=C3)F)F)C4=CC=CC=C4Cl
  • 化学全称
    N-[4-(2-chlorophenyl)-6,7-dimethyl-3-quinolinyl]-N'-(2,4-difluorophenyl)-urea

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Sugiyama Y, et al. Atherosclerosis. 1995 Feb;113(1):71-8. 2. Sugiyama Y, et al. Atherosclerosis. 1995 Nov;118(1):145-53. 3. Tawada H, et al. J Med Chem. 1994 Jun 24;37(13):2079-84.
产品手册
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