TMP-153
CAS No. 128831-46-9
TMP-153 ( TMP153 )
产品货号. M11175 CAS No. 128831-46-9
TMP-153 是一种有效的酰基辅酶A:胆固醇酰基转移酶 (ACAT) 抑制剂,对多种动物的肝脏和肠道 ACAT 的 IC50 为 5-10 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ¥2822 | 有现货 |
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| 5MG | ¥4674 | 有现货 |
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| 10MG | ¥6774 | 有现货 |
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| 25MG | ¥9858 | 有现货 |
|
| 50MG | ¥12834 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称TMP-153
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述TMP-153 是一种有效的酰基辅酶A:胆固醇酰基转移酶 (ACAT) 抑制剂,对多种动物的肝脏和肠道 ACAT 的 IC50 为 5-10 nM。
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产品描述TMP-153 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor with IC50 of 5-10 nM for the hepatic and intestinal ACAT from various animals; inhibits cholesterol esterification both in human colonic adenocarcinoma cells, LS180, and in human hepatoma cells, HepG2 (IC50 = 150 nM and 330 nM, respectively); inhibits cholesterol absorption and lowers plasma cholesterol in rats and hamsters.Hypercholesterolemia Discontinued.
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体外实验——
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体内实验——
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同义词TMP153
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通路Others
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靶点Other Targets
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受体Other Targets
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研究领域Cardiovascular Disease
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适应症Hypercholesterolemia
化学信息
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CAS Number128831-46-9
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分子量437.9
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分子式C24H18ClF2N3O
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纯度>98% (HPLC)
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溶解度——
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SMILESCC1=CC2=C(C(=CN=C2C=C1C)NC(=O)NC3=C(C=C(C=C3)F)F)C4=CC=CC=C4Cl
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化学全称N-[4-(2-chlorophenyl)-6,7-dimethyl-3-quinolinyl]-N'-(2,4-difluorophenyl)-urea
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
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8-Hydroxygenistein
8-Hydroxygenistein (8-OHG) is an antioxidant that can effectively scavenge nitric oxide (NO) and superoxide anion (O??). 8-Hydroxygenistein belongs to ortho-dihydroxy isoflavones (ODI) and is abundantly present in dark soy sauce and light soy sauce. Its antioxidant activity is stronger than that of its parent compound genistein .
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26Rfa, Hypothalamic ...
This human neuropeptide of the RFamide peptide family with orexigenic activity may be also involved in the control of feeding behavior. The 26RFa gene is exclusively expressed in the ventromedial hypothalamic nucleus and in the lateral hypothalamic area. The primary structures of human, rat, and frog 26RFa exhibit ≈80% identity. Other data suggest also the potential role of the 26RFa peptide in the control of the gonadotropic axis.
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Hederagenin-28-beta-...
Hederagenin 28-O-β-D-glucopyranosylester 是一种从 Ilex cornuta 中分离出来的三萜皂苷,对 H2O2 诱导的心肌细胞损伤具有保护作用。
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