PQ-912

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PQ-912 (PQ 912, PQ912) 是一种有效的谷氨酰胺酰环化酶 (QC) 抑制剂，可抑制人类、大鼠和小鼠 QC，Ki 为 20-65 nM。

PQ-912 (PQ 912, PQ912)?is a potent glutaminyl cyclase (QC) inhibitor that inhibits human, rat, and mouse QC with Ki of 20-65 nM; shows a favourable profile of the compound for QC engagement coupled to a reduction of pE-Aβ and behavioural improvementsthe first in class inhibitor of glutaminyl cyclases currently being in clinical development for Alzheimer's disease.Alzheimer Disease Phase 2 Clinical.

——

——

PQ 912 | PQ912

Others

Other Targets

Other Targets

Neurological Disease

Alzheimer Disease

1276021-65-8

336.395

C19H20N4O2

>98% (HPLC)

DMSO : 200 mg/mL 594.55 mM

O=C1NC[C@H](C2=CC=C(OCCC)C=C2)N1C3=CC=C4C(NC=N4)=C3

(S)-1-(1H-benzo[d]imidazol-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one

(-20℃)

With Ice Pack

≥ 2 years