INCB040093 ( INCB 040093 | INCB-040093 | Dezapelisib )

产品货号. M11094 CAS No. 1262440-25-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

INCB040093
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

一种新型有效、选择性、口服 PI3Kδ 抑制剂，IC50 为 31 nM。
产品描述

A novel potent, selective, orally available PI3Kδ inhibitor with IC50 of 31 nM; displays 74 to >900-fold selectivity for the other PI3K family members, and does not inhibit a panel of 57 additional kinases; potently inhibits cellular proliferation CD19+ human or CD21+ canine primary B cells with IC50 of 1-3 nM, reduces anti-FcR-induced basophil activation in the presence of human whole blood (IC50=33 nM); demonstrates promising efficacy in patients with Hodgkin's lymphoma in clinical studies.Blood Cancer Phase 2 Clinical.
体外实验

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体内实验

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同义词

INCB 040093 | INCB-040093 | Dezapelisib
通路

PI3K/Akt/mTOR signaling
靶点

PI3K
受体

PI3K
研究领域

Cancer
适应症

Blood cancer

CAS Number

1262440-25-4
分子量

421.454
分子式

C20H16FN7OS
纯度

>98% (HPLC)
溶解度

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SMILES

O=C1C(C2=CC=CC(F)=C2)=C([C@@H](NC3=C4N=CNC4=NC=N3)C)N=C5N1C(C)=CS5
化学全称

6-(3-fluorophenyl)-3-methyl-7-((1S)-1-(9H-purin-6-ylamino)ethyl)-5H-(1,3)thiazolo(3,2-a)pyrimidin-5-one

1. Shin N, et al. J Pharmacol Exp Ther. 2017 Nov 10. pii: jpet.117.244947.

计算器

产品手册

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