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CHF6001
CAS No. 1239278-59-1
CHF6001 ( CHF-6001 | CHF 6001 )
产品货号. M10961 CAS No. 1239278-59-1
一种新型、高效、选择性磷酸二酯酶 4 (PDE4) 抑制剂，IC50 为 0.026 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥3772 | 有现货 |
|
| 10MG | ￥5672 | 有现货 |
|
| 25MG | ￥8240 | 有现货 |
|
| 50MG | ￥11346 | 有现货 |
|
| 100MG | ￥14670 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称CHF6001
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述一种新型、高效、选择性磷酸二酯酶 4 (PDE4) 抑制剂，IC50 为 0.026 nM。
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产品描述A novel, highly potent and selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 0.026 nM; inhibits PDE4 isoforms A-D with equal potency, 7- and 923-fold more potent than roflumilast and cilomilast, and displays >20,000-fold selectivity versus PDE4 compared with a panel of PDEs; effectively inhibits (subnanomolar IC50 values) the release of TNF-α from human PBMCs, THP-1, and rodent macrophages; inhibitsLPS-induced pulmonary neutrophilia (ED50=0.205 uM/kg) and leukocyte infiltration (ED50=0.188 uM/kg) in rats.COPD Phase 2 Clinical.
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体外实验——
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体内实验——
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同义词CHF-6001 | CHF 6001
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通路Angiogenesis
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靶点PDE
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受体PDE
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研究领域Inflammation/Immunology
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适应症COPD
化学信息
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CAS Number1239278-59-1
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分子量687.533
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分子式C30H30Cl2F2N2O8S
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(O[C@H](C1=CC=C(OC(F)F)C(OCC2CC2)=C1)CC3=C(Cl)C=[N+]([O-])C=C3Cl)C4=CC=C(NS(=O)(C)=O)C(OCC5CC5)=C4
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化学全称(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3-(cyclopropylmethoxy)-4-(methylsulfonamido)benzoyloxy)ethyl)pyridine 1-oxide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Armani E, et al. J Med Chem. 2014 Feb 13;57(3):793-816.
2. Villetti G, et al .J Pharmacol Exp Ther. 2015 Mar;352(3):568-78.
3. Moretto N, et al. J Pharmacol Exp Ther. 2015 Mar;352(3):559-67.
4. Edwards MR, et al. Pharmacol Res Perspect. 2016 Jan 15;4(1):e00202.
产品手册
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