PF-05150122 ( PF05150122 )

产品货号. M10944 CAS No. 1235406-03-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

PF-05150122
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

PF-05150122 是一种有效的、状态依赖性、亚型选择性 Nav1.7 抑制剂，IC50 为 21 nM。
产品描述

PF-05150122 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5.Pain Phase 1 Discontinued.
体外实验

PF-05186462 inhibits human Nav1.7 channels (IC50=21 nM) in HEK293 cells.PF-05186462 exhibits a high plasma protein binding rate.
体内实验

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同义词

PF05150122
通路

Membrane Transporter/Ion Channel
靶点

Sodium Channel
受体

Sodium Channel
研究领域

Neurological Disease
适应症

Pain

CAS Number

1235406-03-7
分子量

531.885
分子式

C19H10ClF4N5O3S2
纯度

>98% (HPLC)
溶解度

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SMILES

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化学全称

5-chloro-2-fluoro-4-(2-(pyridazin-4-yl)-4-(trifluoromethyl)phenoxy)-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

1. Swain NA, et al. J Med Chem. 2017 Aug 24;60(16):7029-7042. 2. Jones HM, et al. Clin Pharmacokinet. 2016 Jul;55(7):875-87.

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产品手册

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