Idasanutlin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Idasanutlin (RG-7388) 是一种有效的选择性 p53-MDM2 抑制剂，IC50 为 6 nM。

Idasanutlin (RG-7388) is a potent and selective p53-MDM2 inhibitor with IC50 of 6 nM.(In Vitro):Idasanutlin (RG7388) inhibits cell proliferation with IC50 of 30 nM, and induces dose-dependent p53 stabilization, cell cycle arrest, as well as cell apoptosis in cancer cells expressing wild-type p53. Idasanutlin (RG7388) (300 nM or 1.8 μM) induces apoptosis in SJSA osteosarcoma cells.(In Vivo):Idasanutlin (RG7388, 25 mg/kg p.o.) results in tumor growth inhibition and regression, in the mouse SJSA human osteosarcoma xenograft model. Idasanutlin (RG7388) induces induction of apoptosis and antiproliferation, in the SJSA xenograft model.

——

——

RG-7388

Apoptosis

MDM2-p53

Mdm2

Cancer

——

1229705-06-9

616.48

C31H29Cl2F2N3O4

>98% (HPLC)

DMSO:100 mg/mL (162.21 mM); Ethanol:8 mg/mL warmed (12.97 mM); Water：<1 mg/mL (<1 mM)

O=C(O)C1=CC=C(NC([C@@H]2N[C@@H](CC(C)(C)C)[C@](C#N)(C3=CC=C(Cl)C=C3F)[C@H]2C4=CC=CC(Cl)=C4F)=O)C(OC)=C1

4-((2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxamido)-3-methoxybenzoic acid.

(-20℃)

With Ice Pack

≥ 2 years