DS-7423

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

DS-7423 是一种新型强效小分子 PI3K/mTOR 双重抑制剂。

DS-7423 is a novel potent, small-molecule dual inhibitor of PI3K/mTOR with IC50 of 15.6, 1143, 249, 262 and 34.9 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, and mTOR? respectively; exerts anti-tumor effect against a panel of nine OCCA cell lines with IC50 of <75 nM, regardless of the mutational status of PIK3CA; suppresses the tumor growth of OCCA in a dose-dependent manner in mouse xenograft models.Solid Tumors Phase 1 Discontinued.

DS-7423 increases TP53 expression, the level of p-TP53 on Ser-46, and induced apoptosisrelated TP53 target genes (TP53AIP1 and PUMA) in OCCC cells.DS-7423 also inhibits other isoforms of class I PI3K (IC50 values: PI3Kβ = 1,143 nM; PI3Kγ = 249 nM; PI3Kδ = 262 nM).

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DS7423 | DS 7423

PI3K/Akt/mTOR signaling

PI3K

PI3K

Cancer

Solid Tumors

1222104-37-1

520.52

C22H27F3N10O2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (192.12 mM)

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(R)-1-(4-(2-(2-aminopyrimidin-5-yl)-6-morpholino-9-(2,2,2-trifluoroethyl)-9H-purin-8-yl)-2-methylpiperazin-1-yl)ethan-1-one

(-20℃)

With Ice Pack

≥ 2 years