CP-31398 dihydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CP-31398 是一种小分子 p53 重激活剂，可保护 p53 免受热变性。

CP-31398 is a small molecule p53 reactivator that protects p53 from thermal denaturation, not only reactivates mutant p53 but also induces stabilization of wild type p53; shows anti-tumor activity in vivo in a transgenic UPII-SV40T mouse model of bladder transitional cell carcinoma.

CP-31398 (36.75 μM, 16 h) induces p21 in p53-mutant cells.CP-31398 (15 μg/mL, 20 hours) could induce apoptosis and cell cycle arrest in SW480 cells. Western Blot Analysis Cell Line:Saos-2 cells expressing transfected mutant p53.Concentration:36.75 μM.Incubation Time:16 h.Result:Induction of p21 in cells expressing only mutant p53.Western Blot Analysis Cell Line:LN-18 and U87MG cells.Concentration:36 μM.Incubation Time:16 h. Result:Decreased the levels of procaspase 3 and induced cleavage of caspase 7.

CP-31398 (100 mg/kg, orally) exhibits significant anti-tumor activity in mice models. Animal Model:Small human tumor xenografts in mice.Dosage:100 mg/kg.Administration:Orally twice daily for 7 days.Result:Suppressed A375.S2 tumor growth by -50%.

CP31398 dihydrochloride

Apoptosis

MDM2-p53

MDM2-p53

Cancer

——

1217195-61-3

435.39

C22H26N4O.2HCl

>98% (HPLC)

In Vitro:?DMSO : 200 mg/mL (459.36 mM)

CN(C)CCCNC1=C2C=CC=CC2=NC(/C=C/C3=CC=C(OC)C=C3)=N1.[H]Cl.[H]Cl

N'-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanediamine dihydrochloride

(-20℃)

With Ice Pack

≥ 2 years