Dapoxetine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

用于蛋白质组学研究的专用产品。

A specialty product for proteomics research.

Dapoxetine binds to 5-HT, norepinephrine, and dopamine reuptake transporters and inhibits 5-HT, norepinephrine, and dopamine uptake with an order of potency: 5-HT >norepinephrine?dopamine.Dapoxetine inhibits the uptake of [3H]5-HT by the 5-HT reuptake transporter with a value of 1.12 nM, and Dapoxetine inhibits the uptake of [3H]norepinephrine into cells utilizing the norepinephrine reuptake transporter and uptake of [3H]dopamine by the dopamine reuptake transporter with IC50 values of 202 nM and 1720 nM, respectively.

Dapoxetine (oral gavage; 1-10 mg/kg; once daily) significantly inhibits testosterone mediated increase in the prostate weight and relative prostate weight and attenuates testosterone-induced prostatic hyperplasia in rats. Animal Model:Adult male Wistar rats Dosage:1 mg/kg, 5 mg/kg, 10 mg/kg Administration:Oral gavage; 1-10 mg/kg; once daily Result:Reverted most of the changes made by testosterone injection.

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Neuroscience

Other Targets

5-HT1A| 5-HT1B| 5-HT2C

Neurological Disease

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119356-77-3

305.42

C21H23NO

>98% (HPLC)

DMSO: 10 mM

CN(C)[C@@H](CCOC1=CC=CC2=CC=CC=C21)C3=CC=CC=C3

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(-20℃)

With Ice Pack

≥ 2 years