021-51111890/在线客服
购物车（）
sales@molnova.cn
  • 咨询热线
    客服服务热线 13671568941/15317326293
  • 在线咨询
    963389683
  • 微信客服
    微信客服
  • 公众号
    扫码关注公众号
首页- Products - Endocrinology/Hormones - Opioid Receptor - (-)-U-50488 hydrochloride

(-)-U-50488 hydrochloride

CAS No. 114528-79-9

(-)-U-50488 hydrochloride ( U50488 | U-50488 )

产品货号. M10515 CAS No. 114528-79-9

(±)-U-50488 活性更强的对映体，是一种有效的选择性 κ 阿片受体激动剂，无 μ 阿片拮抗剂作用。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
200MG ￥11875 有现货
500MG ￥22559 有现货
1G 获取报价 有现货
产品询价 大包装询价 加入购物车

生物学信息

  • 产品名称
    (-)-U-50488 hydrochloride
  • 注意事项
    本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
  • 产品简述
    (±)-U-50488 活性更强的对映体，是一种有效的选择性 κ 阿片受体激动剂，无 μ 阿片拮抗剂作用。
  • 产品描述
    The more active enantiomer of (±)-U-50488, a potent, selective kappa-opioid receptor agonist with no μ-opioid antagonist effects; shows analgesic, diuretic and antitussive effects, and reverses the memory impairment produced by anticholinergic drugs in vivo.Anxiety Discontinued.
  • 体外实验
    (-)-U-50488 hydrochloride (1 pM-100 nM; 7 days) exhibits a concentration-dependent inhibition of HIV-1 expression, the maximal inhibition at 10?13 M (approximately 73% suppression) in acutely infected blood monocyte-derived macrophages (MDM).(-)-U-50488 hydrochloride (10-13 M; 7-14 days) (10?13 M) markedly inhibits HIV-1 expression both at 7 and 14 days after infection, it has a sustained inhibitory effect on HIV-1 infection in MDM.
  • 体内实验
    (-)-U-50488 hydrochloride (intraperitoneal?injection?; 5mg/kg; 2 hrs before 4% paraformaldehyde (PFA)) acutely induced pMeCP2-S421 (phosphorylation of the methyl-DNA binding protein MeCP2 at Ser421) and Fos selectively in the nucleus accumbens (NAc) but does not alter MeCP2 levels in any brain region. Animal Model:C57BL/6J mice Dosage:5 mg/kg Administration:Intraperitoneal?injection; single dose; 2 hrs before 4% PFAResult:Induced pMeCP2-S421 in the brain acutely.
  • 同义词
    U50488 | U-50488
  • 通路
    Endocrinology/Hormones
  • 靶点
    Opioid Receptor
  • 受体
    Opioid Receptor
  • 研究领域
    Neurological Disease
  • 适应症
    Anxiety

化学信息

  • CAS Number
    114528-79-9
  • 分子量
    405.79
  • 分子式
    C19H26Cl2N2O.HCl
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?H2O : 50 mg/mL (123.22 mM)
  • SMILES
    CN(C1CCCCC1N2CCCC2)C(=O)CC3=CC(=C(C=C3)Cl)Cl.Cl
  • 化学全称
    trans-(-)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Tao PL, et al. Eur J Pharmacol. 1994 May 2;256(3):281-6. 2. Suarez-Roca H, et al. J Pharmacol Exp Ther. 1993 Feb;264(2):648-53. 3. Su MT, et al. Br J Pharmacol. 1998 Feb;123(4):625-30. 4. Vonvoigtlander PF, et al. J Pharmacol Exp Ther. 1983 Jan;224(1):7-12.
计算器

浓度计算器

摩尔计算器

分子量计算器

产品手册
关联产品

  • LY-2940094

    LY2940094 (BTRX-246040) 是一种口服有效的选择性 nociceptin 受体 (NOP 受体) 拮抗剂，对 NOP 受体具有高亲和力(Ki 为 0.105 nM) 和拮抗活力 (Kb=0.166 nM)。LY2940094 可降低动物模型的自身给药酒精依赖。

  • 7,8-Dihydroxy-4-phen...

    7,8-二羟基-4-苯基香豆素抑制金黄色葡萄球菌 DNA 解旋酶的活性。

  • Hemorphin-7

    Hemorphin-7 binds to the angiotensin IV receptor, triggering multiple effects including cellular proliferation and memory enhancement. Hemorphins are endogenous peptides belonging to the family of atypical opioid peptides released from hydrolyzed hemoglobin. Hemorphin-7 is investigated as a potential biomarker for breast cancer.

登录 注册