(-)-U-50488 hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

(±)-U-50488 活性更强的对映体，是一种有效的选择性 κ 阿片受体激动剂，无 μ 阿片拮抗剂作用。

The more active enantiomer of (±)-U-50488, a potent, selective kappa-opioid receptor agonist with no μ-opioid antagonist effects; shows analgesic, diuretic and antitussive effects, and reverses the memory impairment produced by anticholinergic drugs in vivo.Anxiety Discontinued.

(-)-U-50488 hydrochloride (1 pM-100 nM; 7 days) exhibits a concentration-dependent inhibition of HIV-1 expression, the maximal inhibition at 10?13 M (approximately 73% suppression) in acutely infected blood monocyte-derived macrophages (MDM).(-)-U-50488 hydrochloride (10-13 M; 7-14 days) (10?13 M) markedly inhibits HIV-1 expression both at 7 and 14 days after infection, it has a sustained inhibitory effect on HIV-1 infection in MDM.

(-)-U-50488 hydrochloride (intraperitoneal?injection?; 5mg/kg; 2 hrs before 4% paraformaldehyde (PFA)) acutely induced pMeCP2-S421 (phosphorylation of the methyl-DNA binding protein MeCP2 at Ser421) and Fos selectively in the nucleus accumbens (NAc) but does not alter MeCP2 levels in any brain region. Animal Model:C57BL/6J mice Dosage:5 mg/kg Administration:Intraperitoneal?injection; single dose; 2 hrs before 4% PFAResult:Induced pMeCP2-S421 in the brain acutely.

U50488 | U-50488

Endocrinology/Hormones

Opioid Receptor

Opioid Receptor

Neurological Disease

Anxiety

114528-79-9

405.79

C19H26Cl2N2O.HCl

>98% (HPLC)

In Vitro:?H2O : 50 mg/mL (123.22 mM)

CN(C1CCCCC1N2CCCC2)C(=O)CC3=CC(=C(C=C3)Cl)Cl.Cl

trans-(-)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride

(-20℃)

With Ice Pack

≥ 2 years