Dexmedetomidine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Dexmedetomidine ((+)-Medetomidine) 是一种有效，选择性和具有口服活性的 α2 肾上腺素能受体 (α2-adrenoceptor) 激动剂，Ki 值为 1.08 nM。Dexmedetomidine 对 α1 肾上腺素受体显示出 1620 倍的选择性。Dexmedetomidine 具有抗焦虑作用，可用于促进睡眠和缓解疼痛的研究。

Dexmedetomidine is a sedative medication used by intensive care units and anesthetists.(In Vitro):Medetomidine has high selectivity for α2 adrenoceptors (Ki=1.08 nM) over α1 adrenoceptors (Ki=1750 nM) in rat brain membranes as measured by the displacement of [3H]clonidine.Medetomidine (0.1-100 nM) inhibits the twitch response in field-stimulated mouse vas deferens, with a pD2 of 9.0.(In Vivo):Medetomidine (10-100 μg/kg; i.v. at 5-min intervals) produces a dose-dependent pupillary dilatation in pentobarbitone-anaesthetized rats.

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Animal Model:Female Sprague-Dawley rats (270-350 g) Dosage:1, 5, 10, 50, 100 mg/kg Administration:I.v. at 5-min intervals Result:Produced the pupil dilatation of 2.5 mm (approximately half of the maximum effect) at the cumulative dose of 4 μg/kg.

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Endocrinology/Hormones

Adrenergic Receptor

α2 receptor

Neurological Disease

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113775-47-6

200.28

C13H16N2

>98% (HPLC)

Ethanol: 40 mg/mL (199.72 mM); Water: 40 mg/mL (199.72 mM); DMSO: 40 mg/mL (199.72 mM)

CC1=C(C(=CC=C1)[C@H](C)C2=CN=CN2)C

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(-20℃)

With Ice Pack

≥ 2 years