Adapalene

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

阿达帕林是一种外用维A酸，主要用于治疗痤疮，也用于（标签外）治疗毛周角化症以及其他皮肤病。

Adapalene is a topical retinoid primarily used in the treatment of acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions. It is currently marketed by Galderma under the trade names Differin in some countries, and Adaferin in India. (In Vitro):Adapalene (1-200 μM; 24 h) inhibits the viability of ES-2, HOV-7, MCF-7 , Hela, SW1990, HT1080, and MM-468 cells, with IC50s of 10.36 μM, 10.81 μM, 12.00 μM, 19.08 μM, 19.52 μM, 21.70 μM, and 31.47 μM, respectively.Adapalene (10-40 μM; 24 h) induces ES-2 cells apoptosis and inhibits proliferation in vitro.Adapalene (3-30 μM; 6-24 h) significantly increases the G1-phase population in LoVo or DLD1 cells.Adapalene (1-200 μM) inhibits GOT1 activity, with an IC50?of 21.79?μM.Adapalene (10-6-10-3 nM) inhibits the expression of plasma membrane-associated enzyme transglutaminase Type I, with an IC50 of 2.5 nM.(In Vivo):Adapalene (15-100 mg/kg; p.o. daily for 21 days) inhibits the growth of DLD1 cell-derived xenograft tumors in BALB/C nude mice.

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Animal Model:Female BALB/C nude mice (15 g, 4-5 weeks) were injected with DLD1 cells Dosage:15, 20, 65, 100 mg/kg Administration:P.o. daily for 21 days Result:Significantly reduced tumor weight and volume.

CD 271

Metabolic Enzyme/Protease

Retinoid Receptor

RAR| RXR

Inflammation/Immunology

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106685-40-9

412.52

C28H28O3

>98% (HPLC)

DMSO: 8 mg/mL (19.39 mM)

COC1=C(C=C(C=C1)C2=CC3=C(C=C2)C=C(C=C3)C(=O)O)C45CC6CC(C4)CC(C6)C5

6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid

(-20℃)

With Ice Pack

≥ 2 years