BAY 80-6946

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BAY 80-6946 (Copanlisib) 是一种有效的、高选择性的可逆 PI3K 抑制剂，针对 PI3Kα/β，IC50 为 0.469 nM/3.72 nM。

BAY 80-6946 (Copanlisib) is a potent and highly selective reversible PI3K inhibitor for PI3Kα/β with IC50 of 0.469 nM/3.72 nM. Phase 2.

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Animal Model:Athymic nude rats injected with KPL4 tumor cells Dosage:0.5 mg/kg, 1 mg/kg, 3 mg/kg or 6 mg/kg.Administration:Intravenous injection; every second day, every third day; for 60 days Result:On day 25, tumor growth inhibition (TGI) rates of 77%, 84%, 99%, and 100% were observed at doses of 0.5, 1, 3, and 6 mg/kg, respectively. All rats remained tumor free at the termination of the study on day 73.

Copanlisib

PI3K/Akt/mTOR signaling

PI3K

PI3Kα| PI3Kβ| PI3Kγ| PI3Kδ

Cancer

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1032568-63-0

480.52

C23H28N8O4

>98% (HPLC)

DMSO:0.002 mg/mL (0.0 mM); Ethanol:0.01 mg/mL (0.02 mM); Water:0.002 mg/mL

COC1=C(C=CC2=C1N=C(N3C2=NCC3)NC(=O)C4=CN=C(N=C4)N)OCCCN5CCOCC5

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(-20℃)

With Ice Pack

≥ 2 years