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CARM1-IN-7g
CAS No. 1020399-49-8
CARM1-IN-7g ( Protein Arginine Methyltransferase 4/Coactivator-Associated Arginine Methyltransferase 1 Inhibitor )
产品货号. M10096 CAS No. 1020399-49-8
CARM1-IN-7g 是一种有效的、选择性的共激活剂相关精氨酸甲基转移酶 1 (CARM1)，IC50 为 8.6 uM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥787 | 有现货 |
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| 10MG | ￥1254 | 有现货 |
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| 25MG | ￥2465 | 有现货 |
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| 50MG | ￥3990 | 有现货 |
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| 100MG | ￥5373 | 有现货 |
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| 200MG | ￥7398 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥938 | 有现货 |
|
生物学信息
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产品名称CARM1-IN-7g
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述CARM1-IN-7g 是一种有效的、选择性的共激活剂相关精氨酸甲基转移酶 1 (CARM1)，IC50 为 8.6 uM。
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产品描述CARM1-IN-7g is a potent, selective coactivator-associated arginine methyltransferase 1 (CARM1) with IC50 of 8.6 uM, exhibits lower or no activity against a panel of different PRMTs or HKMTs (>80-fold over PRMT1 and SET7); inhibits CARM1-mediated methylation of different substrates (PABP1, CA150, SmB, and H3) up to single-digit micromolar level, significantly and dose-dependently reduces the prostate-specific antigen (PSA) promoter activity in human prostate cancer LNCaP cells, does not affect cell viability.
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体外实验——
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体内实验——
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同义词Protein Arginine Methyltransferase 4/Coactivator-Associated Arginine Methyltransferase 1 Inhibitor
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通路Chromatin/Epigenetic
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靶点HMTase
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受体HMTase
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研究领域Cancer
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适应症——
化学信息
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CAS Number1020399-49-8
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分子量555.2578
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分子式C26H21Br2NO3
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 35 mg/mL
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SMILESO=C1/C(CN(CC2=CC=CC=C2)C/C1=C/C3=CC=C(O)C(Br)=C3)=C\C4=CC=C(O)C(Br)=C4
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化学全称4-Piperidinone, 3,5-bis[(3-bromo-4-hydroxyphenyl)methylene]-1-(phenylmethyl)-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Cheng D, et al. J Med Chem. 2011 Jul 14;54(13):4928-32.
