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LOM612
CAS No. 2173232-79-4
LOM612 ( ——— )
产品货号. M39454 CAS No. 2173232-79-4
LOM612 有效对 FOXO 胞质-胞核穿梭进行定位，在 U2fox RELOC 细胞中 EC50 值为 1.5 μM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥1853 | 有现货 |
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| 25MG | 获取报价 | 有现货 |
|
| 50MG | 获取报价 | 有现货 |
|
| 100MG | 获取报价 | 有现货 |
|
生物学信息
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产品名称LOM612
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述LOM612 有效对 FOXO 胞质-胞核穿梭进行定位，在 U2fox RELOC 细胞中 EC50 值为 1.5 μM。
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产品描述LOM612 is a potent FOXO relocator, with an EC50 value of 1.5 μM in U2fox RELOC cells.
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体外实验———
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体内实验LOM612 potently activates nuclear translocation of FOXO with an EC50 value of 1.5 μM, and this effect is independent of CRM-1. LOM612 effectively induces translocation of endogenous FOXO3a and FOXO1, and increases the expression of the FOXO target genes p27 and FasL. LOM612 shows no effect on the nuclear export of endogenous NFKB2 transcription factor in U2OS cells. LOM612 is cytotoxic to HepG2 cells, with an IC50 value of 0.64 μM, and does not sensitize non-cancer THLE2 cells (IC50, 2.76 μM).
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同义词———
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通路Others
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靶点Other Targets
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受体FOXO
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研究领域———
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适应症———
化学信息
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CAS Number2173232-79-4
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分子量258.3
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分子式C13H10N2O2S
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纯度>98% (HPLC)
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溶解度DMSO : 6 mg/mL (23.23 mM; ultraphonic; )
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SMILES———
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化学全称———
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Cautain B, et al. Discovery of a Novel, Isothiazolonaphthoquinone-Based Small Molecule Activator of FOXO Nuclear-Cytoplasmic Shuttling. PLoS One. 2016 Dec 9;11(12):e0167491.?
