L189

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

L189 是一种人 DNA 连接酶抑制剂，抑制 hLigI/III/IV (IC50: 5/9/5 μM)。

L189 is a DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding. L189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ). L189 specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents. L189 will not only provide insights into the cellular function of these enzymes but also serve as lead compounds for the development of anticancer agents.

L189 inhibits DNA Ligase I, III and IV activity with IC50 values of 5 μM, 9 μM and 5 μM, respectively.L189 (5 μM, 48 h) bring good anti-proliferation activity preferentially and cause cell death by creating a cytotoxic environment.L189 (5 μM, 48 h) reduces HeLa nuclear staining along with TMZ.L189 (5 μM, 48 h) enhances TMZ-induced HeLa growth arrestwhen along with TMZ that possibly in G2/M cell cycle phase without employing cell death mechanisms. Cell Cytotoxicity Assay Cell Line:HeLa cells Concentration:5 μM Incubation Time:48 h Result:Blocked to HeLa growth and proliferation along with TMZ and not mark the significant cell cytotoxicity alone.

——

L189 | L 189 | L-189

Others

Other Targets

DNA Ligase I| DNA Ligase III| DNA Ligase IV

Cancer

——

64232-83-3

246.29

C11H10N4OS

>98% (HPLC)

DMSO : ≥ 33 mg/mL; 33.99 mM

Nc1[nH]c(=S)[nH]c(=O)c1\N=C\c1ccccc1

(E)-6-amino-5-(benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

(-20℃)

With Ice Pack

≥ 2 years