L-BUTHIONINE-(SR)-SULFOXIMINE

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

L-Buthionine-(S,R)-sulfoximine 是一种细胞渗透性、不可逆的 γ-谷氨酰半胱氨酸合成酶 (Ki <100 μM) 抑制剂，通过消耗 GSH 诱导细胞氧化应激。

L-Buthionine-(SR)-sulfoximine is a cell-permeable and irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM) that induces oxidative stress in cells by depleting GSH.

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Animal Model:C57BL/6J pun/pun mice.Dosage:2 mM L-Buthionine-(S,R)-sulfoximine (BSO), 20 mM BSO, 2 mM BSO and 20 mM NAC, 20 mM NAC or unsupplemented water for 18 days from 0.5 to 18.5 d.p.c. The pH of supplemented water is as follows: 6.88, 20 mM BSO; 3.37, 2 mM BSO; 2.65, 2 mM BSO plus 20 mM NAC; and 2.58, 20 mM NAC. The pH of regular water used in our facility is ~4. Administration:Drinking water.Result:The average number of eye-spots (mean±SEM) is 5.36±0.29 (n=46), 7.79±0.45 (n=34) and 8.78±0.61 (n=32) in untreated controls, 2 mM L-Buthionine-(S,R)-sulfoximine (BSO) and 20 mM BSO treated mice, respectively. The 2 mM BSO treatment results in ~30% more eye-spots, and the 20 mM treatment results in 40% more eye-spots compared with untreated mice.

L-Butionine sulfoximine

Others

Other Targets

γ-glutamylcysteine synthetase

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83730-53-4

222.31

C8H18N2O3S

>98% (HPLC)

H2O:41.67 mg/mL (187.44 mM; Need ultrasonic)

CCCCS(=N)(=O)CC[C@H](N)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years