JD-5037

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种选择性外周限制性大麻素 1 (CB1) 受体阻断剂，IC50 为 1.5 nM。

A selective, peripherally restricted cannabinoid-1(CB1) receptor blocker with IC50 of 1.5 nM; shows no effect on CB2 (>10 uM); equieffective with its brain-penetrant parent compound in reducing appetite, body weight, hepatic steatosis, and insulin resistance, even though it does not occupy central CB1R or induce related behaviors.

——

——

JD 5037 | JD5037

GPCR/G Protein

Cannabinoid Receptor

CB1R

Metabolic Disease

——

1392116-14-1

572.506

C27H27Cl2N5O3S

>98% (HPLC)

DMSO: 10 mM

CC(C)[C@@H](C(N)=O)/N=C(N1N=C(C2=CC=C(Cl)C=C2)[C@@H](C3=CC=CC=C3)C1)/NS(=O)(C4=CC=C(Cl)C=C4)=O

Butanamide, 2-[[[(4S)-3-(4-chlorophenyl)-4,5-dihydro-4-phenyl-1H-pyrazol-1-yl][[(4-chlorophenyl)sulfonyl]amino]methylene]amino]-3-methyl-, (2S)-

(-20℃)

With Ice Pack

≥ 2 years