Isoprocurcumenol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Isoprocurcumenol 是一种愈创木醚型倍半萜烯，可从 Curcuma comosa 中分离得到。Isoprocurcumenol 可以激活 EGFR 信号。Isoprocurcumenol 增加 ERK 和 AKT 的磷酸化。Isoprocurcumenol 可促进角质形成细胞的增殖。

Isoprocurcumenol is a guaiane type sesquiterpene, that can be isolated from Curcuma comosa. Isoprocurcumenol can activate EGFR signaling. Isoprocurcumenol increases the phosphorylation of ERK and AKT. Isoprocurcumenol promotes the proliferation of keratinocytes.

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Isoprocurcumenol (10 μM, 0-1 h) 可促进 ERK 和 AKT 的磷酸化。Isoprocurcumenol (0-200 μM, 24 or 48 h) 诱导角质形成细胞 HaCaT 细胞增殖。Isoprocurcumenol (1 μM, 1 h) 通过激活 EGFR 信号通路增加细胞生长和增殖相关基因的表达，例如 c-fos、c-jun、c-myc 和 egr-1。Isoprocurcumenol 诱导细胞恢复和伤口愈合。Western Blot Analysis Cell Line:HaCaT cells (human keratinocyte cell) Concentration:10 μM Incubation Time:10, 30, or 60 min Result:Induced the phosphorylation of ERK and AKT after 10 min and this was sustained for 1 h.Cell Proliferation Assay Cell Line:HaCaT cells (human keratinocyte cell) Concentration:0 nM, 1 nM, 10 nM, 100 nM, 1 μM, 10 μM, 25 μM, 50 μM, 100 μM, or 200 μM Incubation Time:24 or 48 h Result:Showed a significant increase in the proliferation of cells at most of the Isoprocurcumenol concentrations, starting at 10 nM.RT-PCR Cell Line:HaCaT cells (human keratinocyte cell)Concentration:1 μM Incubation Time:1 h Result:Increased the expression of genes related to cell growth and proliferation, such as c-myc, c-jun, c-fos, and egr-1.

异原莪术烯醇

Others

Other Targets

NO

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102130-90-5

234.33

C15H22O2

>98% (HPLC)

DMSO : 2.4 mg/mL (10.24 mM; ultraphonic; )

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(-20℃)

With Ice Pack

≥ 2 years