Ipivivint

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Ipivivint (compound 38) 是一种有效的 CDC 样激酶 (CLK) 抑制剂，对 CLK2 和 CLK3 的 EC50 分别为 1 nM、7 nM。Ipivivint 抑制 Wnt 通路 (EC50=13 nM)。

Ipivivint (Compound 38) is an orally active and potent CDC-like kinase (CLK) inhibitor with EC50s of 1 nM, 7 nM for CLK2 and CLK3, respectively. Ipivivint inhibits Wnt pathway (EC50=13 nM).

Animal Model:Foxn1 miceDosage:25 mg/kg Administration:P.o.Result:Potently inhibited tumor SRSF6 phosphorylation.

Western Blot Analysis Cell Line:SW480 cells Concentration:0.01~10 μM Incubation Time:1 hourResult:Potently inhibited SRSF5/6 phosphorylation.Apoptosis Analysis Cell Line:SW480 cells Concentration:0.01~10 μM Incubation Time:0.03 μM~3 μM Result:Induced apoptosis.RT-PCR Cell Line:HEK-293T cells Concentration:0.3~3 μM Incubation Time:1 hour Result:Inhibited Wnt/β-catenin signaling induced by Wnt3a. Immunofluorescence Cell Line:SW480 cells Concentration:0.3~10 μM Incubation Time:6 hours Result:Increased nuclear speckle enlargement.

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Others

Other Targets

CDK2: 1 nM (EC50, CDK3: 7 nM (EC50)

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1481617-15-5

464.5

C26H21FN8

>98% (HPLC)

DMSO : 3.33 mg/mL (7.17 mM; ultraphonic (<80°C); )

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(-20℃)

With Ice Pack

≥ 2 years