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Inz-1
CAS No. 897776-15-7
Inz-1 ( Inz1 | Inz 1 )
产品货号. M27886 CAS No. 897776-15-7
Inz-1 是一种有效的真菌选择性线粒体细胞色素 bc1 抑制剂，对酵母和人类的 IC50 分别为 8.092 和 45.320 μM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1280 | 有现货 |
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| 10MG | ￥2155 | 有现货 |
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| 25MG | ￥3872 | 有现货 |
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| 50MG | ￥5654 | 有现货 |
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| 100MG | ￥8060 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Inz-1
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Inz-1 是一种有效的真菌选择性线粒体细胞色素 bc1 抑制剂，对酵母和人类的 IC50 分别为 8.092 和 45.320 μM。
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产品描述Inz-1 is an effective and fungal-selective inhibitor of mitochondrial cytochrome bc1 with IC50s of 8.092 and 45.320 μM for yeast and human. Inz-1 reverses Fluconazole or other triazole antifungals’ resistance in the pathogenic fungus Candida albicans.(In Vitro):Inz-1 against Candida and HepG2 respiring growth with IC50 values of 1.655 uM and >32 μM, respectively. Inz-1 (0-16 μM; 24 hours) inhibits the growth of the model yeast S. cerevisiae (strain BY4741) and C. albicans (SC5314) in media containing glucose or glycerol as the sole carbon source, while only mildly slowing growth in glucose. Inz-1 (0-100 μM; 24 hours) shows inhibition of yeast cytochrome B enzymatic activity in a concentration -dependent manner in both wild-type and F90Y mutant mitochondria. It exhibits inhibition of cytochrome bc1 from both S. cerevisiae and C. albicans with IC50 value of 2.5 μM and 8.0 μM, respectively. Inz-1 (0-100 μM; 24 hours) inhibits proliferation under forced respiration conditions only at 32 μM and only mildly at that concentration.
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体外实验Inz-1 (0-16 μM; 24 hours) inhibits the growth of the model yeast?S. cerevisiae?(strain BY4741) and?C. albicans?(SC5314) in media containing glucose or glycerol as the sole carbon source, while only mildly slowing growth in glucose.?Inz-1 (0-100 μM; 24 hours) shows inhibition of yeast cytochrome B enzymatic activity in a concentration -dependent manner in both wild-type and F90Y mutant mitochondria. It exhibits inhibition of cytochrome bc1 from both?S. cerevisiae and?C. albicans?with IC50 value of 2.5 μM and 8.0 μM, respectively.Inz-1 (0-100 μM; 24 hours) is selective for yeast over human cytochrome bc1, it inhibits human cytochrome bc1 activity only weakly, with an IC50?of 45.3 μM, 5.6-fold higher than the IC50?for the?C. albicans?homolog in mitochondria purified from HEK293 human embryonic kidney cells.Inz-1 (0-100 μM; 24 hours) inhibits proliferation under forced respiration conditions only at 32 μM，and only mildly at that concentration.Inz-1 is against candida, human enzyme with IC50 values of 8.092μM and 45.320 μM, respectively. It against Candida and HepG2 respiring growth with IC50 values of 1.655 uM and >32 μM, respectively.
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体内实验——
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同义词Inz1 | Inz 1
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通路Metabolic Enzyme/Protease
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靶点P450
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受体Carbonic anhydrase
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研究领域——
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适应症——
化学信息
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CAS Number897776-15-7
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分子量266.3
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分子式C16H14N2O2
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纯度>98% (HPLC)
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溶解度——
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SMILESCOC(=O)Cn1nc(-c2ccccc2)c2ccccc12
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Milburn-McNulty P, et al. Sulthiame add-on therapy for epilepsy. Cochrane Database Syst Rev. 2015 Oct 28;(10):CD009472.
产品手册
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