IMM-01

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

IMM-01 是一类新型的哺乳动物透明 (mDia) 相关福明的小分子激动剂，它在 Rho GTPases 下游发挥作用，组装肌动蛋白丝，并通过微丝进行组织，以在迁移和不对称分裂过程中建立和维持细胞极性。

IMM-01 is a novel class of small-molecule agonists of the mammalian Diaphanous (mDia)-related formins, which act downstream of Rho GTPases to assemble actin filaments, and their organization with microfilaments to establish and maintain cell polarity during migration and asymmetric division. GTP-bound Rho activates mDia family members by disrupting the interaction between the DID and DAD autoregulatory domains, which releases the FH2 domain to modulate actin and microtubule dynamics.

Apoptosis Analysis Cell Line:NIH 3T3 cells and SW480 cells Concentration:1 μM, 10 μM, or 100 μM Incubation Time:48 hours Result:Induced caspase-3 cleavage.

Animal Model:Athymic nude female mice (6 to 8 weeks) implanted with SW480 cells Dosage:5 mg/kg, 25 mg/kg Administration:i.v.; 2 times a week; for 3 weeks Result:Slowed tumor growth in a dose-dependent manner when administered intravenously via the tail vein.

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Others

Other Targets

CYP3A4|Calcium Channel|P-gp

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218795-74-5

267.35

C12H17N3O2S

>98% (HPLC)

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CC(C)(C)NC(=S)N\N=C\c1ccc(O)cc1O

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(-20℃)

With Ice Pack

≥ 2 years