HeE1-2Tyr

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

HeE1-2Tyr 是一种吡啶并苯并噻唑化合物，是一种黄病毒 RNA 依赖性 RNA 聚合酶 (RdRp) 抑制剂。它在体外显着抑制西尼罗河、登革热和 SARS-CoV-2 RdRps（IC50 为 27.6 μM）活性。

HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. It significantly inhibits West Nile, Dengue and SARS-CoV-2 RdRps (IC50 of 27.6 μM) activity in vitro.

HeE1-2Tyr shows antiviral activity, it is able to inhibit an Ugandan strain of West Nile virus with an IC50 of 2.1 μM, as well as all the four Dengue virus (DENV) serotypes, with IC50 ranging from 6.8 to 15 μM. The cytotoxicity of HeE1-2Tyr versus Vero E6 cells is ~115 μM.Additionally, upon infection of human HEK 293 cells (CC50 of 50 μM), HeE1-2Tyr inhibits clinical strains of yellow fever virus with IC50 values ranging from 3.9 to 12 μM. HeE1-2Tyr completely inhibits the replication of both SARS-CoV-2 and Feline coronavirus (FIPV).

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Others

Other Targets

Antibacterial

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2245195-67-7

582.67

C33H30N2O6S

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (171.62 mM)

OC([C@H](Cc(cc1)ccc1O)NC(C(C=C1c2ccccc2)=C2Sc(ccc(OC3CCCCC3)c3)c3N2C1=O)=O)=O

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(-20℃)

With Ice Pack

≥ 2 years