HS-72 ( HS72 )

产品货号. M12733 CAS No. 1800285-51-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

HS-72
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

HS-72 是一种诱导型 Hsp70（Hsp70i 或 Hsp72）的变构、选择性、细胞渗透性抑制剂。
产品描述

HS-72 is an allosteric, selective, cell-permeable inhibitor of inducible Hsp70 (Hsp70i or Hsp72), shows selectivity for Hsp70i over the closely related Hsc70 as well as the broader purinome; inhibits Hsp70i activity in a Huntington’s cell model and across multiple tumorigenic cell lines; causes degradation of HER2 and Akt; is bioavailable in vivo and reduces tumor growth in a spontaneous mouse mammary tumor model; also demonstrates anti-dengue virus activity.
体外实验

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体内实验

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同义词

HS72
通路

Cytoskeleton/Cell Adhesion Molecules
靶点

HSP
受体

HSP
研究领域

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适应症

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CAS Number

1800285-51-1
分子量

364.44
分子式

C20H24N6O
纯度

>98% (HPLC)
溶解度

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SMILES

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化学全称

(S)-N-(1-propyl-1H-benzo[d]imidazol-2-yl)-1-(pyrazin-2-yl)piperidine-3-carboxamide