
HIV-1 integrase inhibitor 8
CAS No. 1568-80-5
HIV-1 integrase inhibitor 8 ( —— )
产品货号. M35466 CAS No. 1568-80-5
HIV-1 integrase inhibitor 8 是 HIV-1 整合酶 (HIV-1 integrase) 抑制剂,化合物 8。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
100MG | ¥306 | 有现货 |
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200MG | ¥428 | 有现货 |
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500MG | ¥704 | 有现货 |
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1G | ¥1017 | 有现货 |
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生物学信息
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产品名称HIV-1 integrase inhibitor 8
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述HIV-1 integrase inhibitor 8 是 HIV-1 整合酶 (HIV-1 integrase) 抑制剂,化合物 8。
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产品描述HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor, compound 8.
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体外实验HIV-1 integrase inhibitor 8 is against 3′-processing (TC) and strand-transfer (ST) activities in the presence of Mn2+ as the cationic cofactor by gel assay with IC50 values of 275 μM and 200 μM, respectively. It inhibits the strand-transfer (ST) activity with an IC50 value of 200 μM.The DNA relaxation activity of MCV topoisomerase is monitored by gel electrophoresis, while DNA cleavage and religation activities were monitored using a microtiter assay. HIV-1 integrase inhibitor 8 inhibits MCV topoisomerase and DNA religation with IC50 values of 500 μM and 200 μM, respectively. This result demonstrates that compound 8 is inactive against topoisomerase in both assays. HIV-1 integrase inhibitor 8 induces cell cytotoxicity and yields a LD50 (dose at which the signal is reduced 50% due to cell death) of 20 μM in HeLa cells.
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体内实验——
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同义词——
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通路Microbiology/Virology
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靶点HIV
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受体HIV Protease
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研究领域——
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适应症——
化学信息
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CAS Number1568-80-5
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分子量308.41
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分子式C21H24O2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 125 mg/mL (405.30 mM; 超声助溶 )
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SMILESCC1(C)CC2(CC(C)(C)c3ccc(O)cc23)c2cc(O)ccc12
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Molteni, et al. A New Class of HIV-1 Integrase Inhibitors: The 3,3,3', 3'-tetramethyl-1,1'-spirobi(indan)-5,5',6,6'-tetrol Family.J Med Chem?