
Ganitumab
CAS No. 905703-97-1
Ganitumab ( —— )
产品货号. M36729 CAS No. 905703-97-1
Ganitumab (AMG 479) 是一种重组人1型胰岛素样生长因子受体 (IGF1R) 单克隆抗体。Ganitumab 识别具有亚纳米摩尔亲和力的小鼠 IGF1R (KD=0.22 nM),并抑制小鼠 IGF1R 与 IGF1 和 IGF2 的相互作用。Ganitumab 可用于癌症研究。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥3734 | 有现货 |
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5MG | ¥6097 | 有现货 |
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10MG | ¥9529 | 有现货 |
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25MG | ¥13920 | 有现货 |
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50MG | ¥18690 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Ganitumab
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Ganitumab (AMG 479) 是一种重组人1型胰岛素样生长因子受体 (IGF1R) 单克隆抗体。Ganitumab 识别具有亚纳米摩尔亲和力的小鼠 IGF1R (KD=0.22 nM),并抑制小鼠 IGF1R 与 IGF1 和 IGF2 的相互作用。Ganitumab 可用于癌症研究。
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产品描述Ganitumab (AMG 479) is a recombinant human monoclonal antibody to the human type 1 insulin-like growth factor receptor (IGF1R). Ganitumab recognizes murine IGF1R with sub-nanomolar affinity (KD=0.22 nM) and inhibits the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab can be used in research of cancer.
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体外实验Western Blot Analysis Cell Line:CT26 cells Concentration:0.032-500 nM Incubation Time:10 minutes Result:Inhibited IGF1-induced autophosphorylation of mIGF1R in CT26 murine colon carcinoma cells in a dose-dependent manner.
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体内实验Animal Model:Na?ve and tumor-bearing miceDosage:1 mg/doseAdministration:Intraperitoneal injectionResult:Inhibited the IGF1-induced activation of mIGF1R and inhibited 80% tumor growth.Animal Model:Male athymic nude mice Dosage:300 μg/dose Administration:Intraperitoneal injection, twice per week for a total of five doses Result:Had significantly higher serum glucose levels than hIgG1-pretreated mice.Increased serum levels of mIGF1, mIGFPB3 and mGH.Animal Model:Female athymic nude mice Dosage:300 μg/dose Administration:Intraperitoneal injection, twice per week for a total of five dosesResult:Reduced the number of peripheral neutrophils up to 50% compared with hIgG1 controls.
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同义词——
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通路Angiogenesis
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靶点IGF-1R
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受体IGF-1R
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研究领域——
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适应症——
化学信息
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CAS Number905703-97-1
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分子量
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分子式——
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纯度>98% (HPLC)
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溶解度——
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SMILES——
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献




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