• 咨询热线
    客服服务热线 13671568941/15317326293
  • 在线咨询
  • 微信客服
    微信客服
  • 公众号
    扫码关注公众号

Ganitumab

CAS No. 905703-97-1

Ganitumab ( —— )

产品货号. M36729 CAS No. 905703-97-1

Ganitumab (AMG 479) 是一种重组人1型胰岛素样生长因子受体 (IGF1R) 单克隆抗体。Ganitumab 识别具有亚纳米摩尔亲和力的小鼠 IGF1R (KD=0.22 nM),并抑制小鼠 IGF1R 与 IGF1 和 IGF2 的相互作用。Ganitumab 可用于癌症研究。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥3734 有现货
5MG ¥6097 有现货
10MG ¥9529 有现货
25MG ¥13920 有现货
50MG ¥18690 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Ganitumab
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Ganitumab (AMG 479) 是一种重组人1型胰岛素样生长因子受体 (IGF1R) 单克隆抗体。Ganitumab 识别具有亚纳米摩尔亲和力的小鼠 IGF1R (KD=0.22 nM),并抑制小鼠 IGF1R 与 IGF1 和 IGF2 的相互作用。Ganitumab 可用于癌症研究。
  • 产品描述
    Ganitumab (AMG 479) is a recombinant human monoclonal antibody to the human type 1 insulin-like growth factor receptor (IGF1R). Ganitumab recognizes murine IGF1R with sub-nanomolar affinity (KD=0.22 nM) and inhibits the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab can be used in research of cancer.
  • 体外实验
    Western Blot Analysis Cell Line:CT26 cells Concentration:0.032-500 nM Incubation Time:10 minutes Result:Inhibited IGF1-induced autophosphorylation of mIGF1R in CT26 murine colon carcinoma cells in a dose-dependent manner.
  • 体内实验
    Animal Model:Na?ve and tumor-bearing miceDosage:1 mg/doseAdministration:Intraperitoneal injectionResult:Inhibited the IGF1-induced activation of mIGF1R and inhibited 80% tumor growth.Animal Model:Male athymic nude mice Dosage:300 μg/dose Administration:Intraperitoneal injection, twice per week for a total of five doses Result:Had significantly higher serum glucose levels than hIgG1-pretreated mice.Increased serum levels of mIGF1, mIGFPB3 and mGH.Animal Model:Female athymic nude mice Dosage:300 μg/dose Administration:Intraperitoneal injection, twice per week for a total of five dosesResult:Reduced the number of peripheral neutrophils up to 50% compared with hIgG1 controls.
  • 同义词
    ——
  • 通路
    Angiogenesis
  • 靶点
    IGF-1R
  • 受体
    IGF-1R
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    905703-97-1
  • 分子量
  • 分子式
    ——
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    ——
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Moody G, et, al. IGF1R blockade with ganitumab results in systemic effects on the GH-IGF axis in mice. J Endocrinol. 2014 Mar 17;221(1):145-55.?
产品手册
关联产品
  • Esculentoside H

    商陆科植物具有抗肿瘤活性,其机制可能与Esculentoside H释放TNF的能力有关。

  • NVP-AEW541

    NVP-AEW541 (AEW-541, AEW541) 是一种有效的选择性 IGF-1R 抑制剂,IC50 为 86 nM。

  • KW-2450 free base

    KW-2450 free base is an orally bioavailable inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) tyrosine kinases with potential antineoplastic activity. IGF-1R/IR inhibitor KW-2450 free base selectively binds to and inhibits the activities of IGF-1R and IR, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-R1 and IR tyrosine kinases, overexpressed in a variety of human cancers, play significant roles in the stimulation of cellular proliferation, oncogenic transformation, and suppression of apoptosis.