GSK-229423 ( GSK229423 )

产品货号. M11427 CAS No. 1352149-24-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

GSK-229423
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

GSK-229423 是一种新型细菌拓扑异构酶抑制剂，可有效抑制金黄色葡萄球菌 DNA 旋转酶的超螺旋，IC50 为 14 nM。
产品描述

GSK-229423 is a novel bacterial topoisomerase inhibitor that shows potent inhibition of supercoiling by DNA gyrase from S. aureus with IC50 of 14 nM; displays approximately 70 times more potent against S. aureus DNA gyrase than NXL101; has potent antibacterial activity against a broad spectrum of Gram-positive and Gram-negative bacterial pathogens, including clinical isolates with fluoroquinolone resistance mediated by DNA gyrase and topo IV mutations.
体外实验

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体内实验

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同义词

GSK229423
通路

GPCR/G Protein
靶点

Antibacterial
受体

Antibacterial
研究领域

——
适应症

——

CAS Number

1352149-24-6
分子量

459.612
分子式

C26H29N5OS
纯度

>98% (HPLC)
溶解度

——
SMILES

N#CC1=C(CCN2CCC(NCC3=CC4=C(OCS4)C=N3)CC2)C5=CC(OC)=CC=C5N=C1
化学全称

4-(2-(4-(([1,3]oxathiolo[5,4-c]pyridin-6-ylmethyl)amino)piperidin-1-yl)ethyl)-6-ethylquinoline-3-carbonitrile

1. Bax BD, et al. Nature. 2010 Aug 19;466(7309):935-40.

计算器

产品手册

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