GMI-1070

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

GMI-1070 (Rivipansel, PF-06460031) 是一种新型小分子糖模拟泛选择素拮抗剂，对 E-选择素、P-选择素和 L-选择素的 IC50 值分别为 4.3 uM、423 uM 和 337 uM。

GMI-1070 (Rivipansel, PF-06460031)?is a novel small molecule glycomimetic pan-Selectin antagonist with IC50 of 4.3 uM, 423 uM and 337 uM for E-selectin, P-selectin and L-selectin, respectively; predominantly inhibits E-selectin-mediated adhesion and dramatically inhibits sRBC-leukocyte interactions, leading to improved microcirculatory blood flow and improved survival; a valuable novel therapeutic intervention for acute sickle cell crises. Anemia, Phase 3 Clinical.

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Rivipansel | PF-06460031

Cytoskeleton/Cell Adhesion Molecules

Selectin

Selectin

Other Indications

Anemia

927881-99-0

1447.421

C58H74N6O31S3

>98% (HPLC)

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O=C(O)[C@@H](O[C@@H]1[C@@H](OC(C2=CC=CC=C2)=O)[C@H](O[C@H]3[C@H](O[C@H]4[C@@H](O)[C@H](O)[C@H](O)[C@H](C)O4)[C@@H](NC(C(NC5=O)=CC(N5)=O)=O)C[C@@H](C(NCCNC(COCCOCC(NC6=C7C(S(=O)(O)=O)=CC(S(=O)(O)=O)=CC7=CC(S(=O)(O)=O)=C6)=O)=O)=O)C3)O[C@H](CO)[C@@H]1O)CC8CCCCC8

8-[[13-[(1R,3R,4R,5S)-3-[[2-O-Benzoyl-3-O-[(1S)-1-carboxy-2-cyclohexylethyl]-b-D-galactopyranosyl]oxy]-4-[(6-deoxy-a-L-galactopyranosyl)oxy]-5-[[(1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinyl)carbonyl]amino]cyclohexyl]-1,8,13-trioxo-3,6-dioxa-9,12-diazatride

(-20℃)

With Ice Pack

≥ 2 years