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GKI-1
CAS No. 2444764-03-6
GKI-1 ( —— )
产品货号. M32936 CAS No. 2444764-03-6
GKI-1是Greatwall (GWL)激酶抑制剂，抑制hGWLFL和hGWL-KinDom的IC50 分别为4.9 和 2.5 μM。GKI-1 可高效抑制 ROCK1，IC50为11 μM, 仅微弱抑制 PKA。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥1912 | 有现货 |
|
| 5MG | ￥3004 | 有现货 |
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| 10MG | ￥4490 | 有现货 |
|
| 25MG | ￥7007 | 有现货 |
|
| 50MG | ￥9540 | 有现货 |
|
| 100MG | ￥12623 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称GKI-1
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述GKI-1是Greatwall (GWL)激酶抑制剂，抑制hGWLFL和hGWL-KinDom的IC50 分别为4.9 和 2.5 μM。GKI-1 可高效抑制 ROCK1，IC50为11 μM, 仅微弱抑制 PKA。
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产品描述GKI-1 is a Greatwall (GWL) kinase inhibitor with IC50s of 4.9 and 2.5 μM against hGWLFL and hGWL-KinDom, respectively. GKI-1 robustly inhibits ROCK1 with an IC50 of 11 μM, but only weakly affected PKA.
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体外实验GKI-1 inhibits full-length human GWL, and shows cellular efficacy. Treatment of HeLa cells (25 and 50 μM, 0-8.5 hours) with GKI-1 reduces ENSA/ARPP19 phosphorylation levels, resulting in a decrease in mitotic events, mitotic arrest/cell death and cytokinesis failure.
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number2444764-03-6
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分子量269.73
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分子式C15H12ClN3
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 200 mg/mL (741.48 mM; 超声助溶 )
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SMILESN(C=1C=C(C=CC1)C=2C=NNC2)C3=CC=C(Cl)C=C3
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Ocasio CA, et al. A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct. Oncotarget. 2016 Nov 1;7(44):71182-71197.?
产品手册
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