Farletuzumab

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Farletuzumab (MORAb-003) 是一种有效的叶酸受体-α (FRα) 抑制剂。Farletuzumab 是一种人源化单克隆抗体，对 FRα 具有高亲和力。Farletuzumab 对过表达 FRα 的细胞具有生长抑制作用。Farletuzumab 可用于癌症研究。

Farletuzumab (MORAb-003) is a potent folate receptor-alpha (FRα) inhibitor. Farletuzumab is a humanized monoclonal antibody with high affinity for FRα. Farletuzumab possesses growth-inhibitory functions on cells overexpressing FRα. Farletuzumab can be used in research of cancer.

Farletuzumab (MORAb-003; 0-10 μg/mL; CHO-FR cells) inhibits FRα-dependent cell growth and increases folate EC50 in a dose-dependent manner.Farletuzumab (0.1-100 μg/mL; IGROV-1 cells; 1 h) mediates tumor cytotoxicity via complement dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC) in vitro.Farletuzumab (0-10 μg/mL; CHO-FR cells) inhibits phosphorylation of proteins by Lyn kinase, a member of the src family of kinases, thereby, blocking a FRa-mediated signaling pathway..Cell Cytotoxicity Assay Cell Line:IGROV-1 cells Concentration:0.1, 1, 10, and 100 μg/mL Incubation Time:1 hours Result:Had significant cytotoxicity at IGROV-1 cells.

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Cell Cycle/DNA Damage

Antifolate

Antifolate

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896723-44-7

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>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years