FTIDC

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

FTIDC 是一种高效、选择性的 mGluR1 受体变构拮抗剂，对人和大鼠 mGluR5 受体显示出非常弱的效力。

FTIDC is a highly potent and selective allosteric antagonist of mGluR1 receptors and shows very weak potency against human and rat mGluR5 receptors. The inhibition of FTIDC for mGluR1 receptors is shown to be in noncompetitive manner and displays IC50 values of 5.8 and 3.1 nM for human and mouse mGluR1 expressed in CHO cells respectively.

FTIDC inhibits L-glutamate-induced increases in intracellular Ca2+ concentrations, with IC50 values of 5.8 nM , 5.8 nM , 3.1 nM , 7.7 nM for human mGluR1a, rat mGluR1a, mouse mGluR1a, human mGluR1b in CHO cells, respectively.

FTIDC (i.p. or p.o.; 1-30 mg/kg) reduces the duration of face-washing behavior elicited in a dosedependent manner and the inhibitory effect is statistically significant at 10 and 30 mg/kg with i.p. and 30 mg/kg with p.o.. Animal Model:Male CD1 (ICR) mice of 6-weeks-old Dosage:1, 3, 10, and 30 mg/kg Administration:I.p. or p.o.Result:Reduced the duration of face-washing behavior elicited in a dosedependent manner and was statistically significant at 10 and 30 mg/kg with i.p. and 30 mg/kg with p.o..

FTIDC

Others

Other Targets

mGluR1

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873551-53-2

358.42

C18H23FN6O

>98% (HPLC)

In Vitro:?DMSO : ≥ 100 mg/mL (279.01 mM)

C1CC(=CCN1C(=O)N(C(C)C)C)c1nnn(c1C)c1c(nccc1)F

4-[1-(2-Fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide

(-20℃)

With Ice Pack

≥ 2 years