FATP1-IN-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

FATP1-IN-1 (compound 5k) 是一种脂肪酸转运蛋白 1(FATP1) 抑制剂。FATP1-IN-1 抑制重组人或小鼠 FATP1 acyl-CoA 合成酶活性，IC50 值分别为 0.046 μM和 0.60 μM。

FATP1-IN-1 (compound 5k) is a fatty acid transport protein 1 (FATP1) inhibitor. FATP1-IN-1 is an inhibition of recombinant human or mouse acyl-CoA synthetase activity of FATP1, with the IC50 values of 0.046 μM or 0.60 μM, respectively.

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FATP1-IN-1 (p.o.; 10 mg/kg) treatment shows the Cmax, AUC and Tmax were 5.5 μg/mL, 36 μg h/mL and 0.33 hours, respectively, and exceeds the mouse IC50 value of 0.22 μM without considering plasma protein binding.Animal Model:Mouse plasma Dosage:10 mg/kg Administration:P.o.Result:The Cmax, AUC and Tmax were 5.5 μg/mL, 36 μg h/mL and 0.33 hours, respectively.

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Others

Other Targets

Others

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1431945-95-7

375.46

C18H22FN5OS

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 62.5 mg/mL (166.46 mM; 超声助溶 )

Fc1ccc(nc1)N1CCN(CC(=O)Nc2nc3CCCCc3s2)CC1

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(-20℃)

With Ice Pack

≥ 2 years