Etiocholanone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Etiocholanolone (5β-Androsterone) 是睾酮的排泄代谢产物，具有抗惊厥活性。

Etiocholanolone (5β-Androsterone) is the excreted?metabolite?of testosterone and has anticonvulsant activity. Etiocholanolone is a less potent?neurosteroid positive allosteric modulator?(PAM) of the?GABAA?receptor than its?enantiomer form.

Etiocholanolone (10 μM) coapplication with GABA leads to an increase in the relative frequency of long openings (fraction of OT3, site A2 effect), but it isineffective at increasing the duration of long openings (site B effect) or at decreasing the relative frequency of the activation-related closed time component (site A1 effect).

Etiocholanolone (intraperitoneal injection; 0-109.1 mg/kg; single dose) exhibits ED50?values of 57.6 and 109.1 mg/kg in the 6-Hz and PTZ tests, respectively. Protective activity in the 6-Hz test of 5β,3α-A persists for 2 h and is shorter than ent-5β,3α-A treatment (3 hours) in mice.

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Membrane Transporter/Ion Channel

Other Targets

GABAA

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53-42-9

290.44

C19H30O2

>98% (HPLC)

DMSO:97 mg/mL?(333.97 mM;?Need ultrasonic)

C[C@](CC1)([C@@H](CC2)[C@H](CC3)[C@H]1[C@@](C)(CC1)[C@H]3C[C@@H]1O)C2=O

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(-20℃)

With Ice Pack

≥ 2 years