Efalizumab

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Efalizumab 是一种靶向 T 细胞的调节剂，是 LFA-1 α 亚基 CD11a 的人源化单克隆抗体。依法珠单抗可抑制 T 细胞激活、皮肤T细胞运输和T细胞粘附到角质形成细胞，可用于斑块银屑病研究。

Efalizumab is a targeted T cell modulator, and is a humanized monoclonal antibody of CD11a, the α subunit of LFA-1. Efalizumab inhibits T cell activation, cutaneous T cell trafficking, and T cell adhesion to keratinocytes, can be used for plaque psoriasis research.

Efalizumab (78 ng/mL-5 mg/mL) induces a leukocytosis and downregulates LFA-1 expression on T cells in the peripheral blood.Efalizumab (78 ng/mL-5 mg/mL) downregulates plate-bound, anti-CD3-stimulated proliferation of PBMC.

Efalizumab shows side effects include bacterial sepsis, viral meningitis, invasive fungal disease and progressive multifocal leukoencephalopathy (PML), a brain infection caused by reactivation of latent JC virus infection.

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Cell Cycle/DNA Damage

Integrin

Integrin

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214745-43-4

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>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years