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E64FC26
CAS No. 2285446-62-8
E64FC26 ( —— )
产品货号. M32900 CAS No. 2285446-62-8
E64FC26 是蛋白质二硫键异构酶 (PDI) 家族的一种有效的泛抑制剂，对 PDIA1、PDIA3、PDIA4、TXNDC5 和 PDIA6 的 IC50 分别为 1.9、20.9、25.9、16.3 和 25.4 μM。E64FC26 显示抗骨髓瘤活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥2132 | 有现货 |
|
| 5MG | ￥3206 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称E64FC26
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述E64FC26 是蛋白质二硫键异构酶 (PDI) 家族的一种有效的泛抑制剂，对 PDIA1、PDIA3、PDIA4、TXNDC5 和 PDIA6 的 IC50 分别为 1.9、20.9、25.9、16.3 和 25.4 μM。E64FC26 显示抗骨髓瘤活性。
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产品描述E64FC26 is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6, respectively. E64FC26 shows anti-myeloma activity.
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体外实验Cell Viability Assay Cell Line:MM.1S BzR cells Concentration:0.01, 0.1, 1, 10, 100 μM Incubation Time:24 hours Result:Showed anti-MM activity , with an EC50 of 0.59 μM.
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体内实验Animal Model:NOD-SCID IL2Rγ-/- (NSG) mice (bearing MM.1S cells) Dosage:2 mg/ kg Administration:i.p.; three days a week for 7days Result:Showed a clear anti-MM effect in this model also, increasing median survival by 2 weeks.
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同义词——
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number2285446-62-8
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分子量340.38
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分子式C19H23F3O2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 100 mg/mL (293.79 mM; 超声助溶 )
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SMILESC(F)(F)(F)C=1C=2C(\C(=C\CCCCCCCC)\C1)=CC(O)=C(O)C2
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Robinson RM, et al. Inhibitors of the protein disulfide isomerase family for the treatment of multiple myeloma. Leukemia. 2019 Apr;33(4):1011-1022.?
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