Digitonin ( Digitin | NSC 23471 | NSC 237417 )

产品货号. M10393 CAS No. 11024-24-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Digitonin
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Digitonin 是从毛地黄植物紫花地黄中提取的一种甾体皂苷（saraponin）。
产品描述

Digitonin is a steroidal saponin (saraponin) obtained from the foxglove plant Digitalis purpurea. It's aglycone is digitogenin, a spirostan steroid. It has been investigated as a detergent, as it effectively water-solubilizes lipids.
体外实验

Digitonin, a detergent that increases cell permeability by binding to cholesterol molecules in the cell membrane, can increase cisplatin accumulation and reduce tumour growth in vitro.
体内实验

In the liver parenchyma the concentrations are of the same magnitude. Measured with the 133Xe-clearance technique, Digitonin does not alter the tumor blood flow. Digitonin enhances the tumor-growth retarding effect of CBDCA given intra-aterially at 5 mg/kg but not at 25 mg/kg.
同义词

Digitin | NSC 23471 | NSC 237417
通路

Others
靶点

Other Targets
受体

Others
研究领域

Other Indications
适应症

——

CAS Number

11024-24-1
分子量

1229.34
分子式

C56H92O29
纯度

>98% (HPLC)
溶解度

DMSO: 10 mM
SMILES

C[C@@H]1CC[C@]2(O[C@H]3[C@H]([C@H]4[C@@H]5CC[C@H]6C[C@H]([C@@H](C[C@@]6([C@H]5CC[C@@]4([C@H]3[C@@H]2C)C)C)O)O[C@@H]7O[C@@H]([C@@H]([C@@H]([C@H]7O)O)O[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O[C@@H]9O[C@@H]([C@@H]([C@@H]([C@H]9O)O[C@@H]%10O[C@@H]([C@H]([C@@H]([C@H]%10O)O)O)CO)O)CO)O[C@@H]%11OC[C@H]([C@@H]([C@H]%11O)O)O)O)CO)CO)O)OC1
化学全称

beta-D-Galactopyranoside, (2alpha,3beta,5alpha,15beta,25R)-2,15-dihydroxyspirostan-3-yl O-beta-D-glucopyranosyl-(1-3)-O-beta-D-galactopyranosyl-(1-2)-O-(beta-D-xylopyranosyl-(1-3))-O-beta-D-glucopyranosyl-(1-4)-

1. Frenkel N, et al. J Phys Chem B. 2014 Dec 18;118(50):14632-9.

计算器

产品手册

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