Didymin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Didymin 具有抗氧化特性。 Didymin 通过抑制神经母细胞瘤中的 N-Myc 和上调 RKIP 来诱导细胞凋亡，可用于神经母细胞瘤治疗。

Didymin has antioxidant property. Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma, may used for neuroblastoma therapy. Didymin may be a potential therapeutic molecule for the treatment of neurodegenerative disorders associated with oxidative stress.

Cell Proliferation Assay Cell Line:A549 and H460 cells Concentration:1 μM, 5 μM, 10 μM, 20 μM Incubation Time:48 h Result:Inhibited cell proliferation in human non-small-cell lung cancer cells.Apoptosis Analysis Cell Line:A549 and H460 cells Concentration:10 μM, 20 μM Incubation Time:12 h, 24 h, 48 h Result:Induced apoptosis in A549 and H460 cells, without affecting the cell cycle distribution.

Animal Model:Male nude mice [6 weeks old; BALB/cA-nu (nu/nu)] injected with A549 cells Dosage:6 mg/kg/day Administration:i.p.; daily for 28 days Result:Inhibited tumor growth in nude mice.

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Others

Other Targets

Others

Neurological Disease

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14259-47-3

594.57

C28H34O14

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (420.48 mM)

C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)Oc1cc(c2C(=O)C[C@H](Oc2c1)c1ccc(cc1)OC)O)O)O)O)O)O)O

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(-20℃)

With Ice Pack

≥ 2 years