DM4

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

DM4可用于制备抗体药物缀合物，是一种抗微管蛋白剂。它可以抑制细胞分裂。

DM4 can be used in the preparation of antibody drug conjugate and it is an antitubulin agent. It can inhibit cell division.

DM4, a structural analogue of maytansine, is a new thiol-containing and potent maytansinoid. DM4 is a cytotoxic maytansinoid drug. It is synthesized in order to link maytansinoids to antibodies via disulfide bonds. Maytansinoids inhibit tubulin polymerization and microtubule assembly and enhance microtubule destabilization, so there is potent suppression of microtubule dynamics resulting in a mitotic block and subsequent apoptotic cell death.

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Ravtansine

Others

Other Targets

Others

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796073-69-3

780.37

C38H54ClN3O10S

>98% (HPLC)

DMSO: 99 mg/mL (126.86 mM; Need ultrasonic)

CO[C@@H]1/C=C/C=C(Cc2cc(N(C(C[C@@H]([C@@]3(O[C@H]3[C@@H]([C@@H]4C[C@]1(NC(O4)=O)O)C)C)OC([C@@H](N(C(CCC(C)(S)C)=O)C)C)=O)=O)C)c(Cl)c(OC)c2)\C

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(-20℃)

With Ice Pack

≥ 2 years