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DHODH-IN-11
CAS No. 1263303-95-2
DHODH-IN-11 ( —— )
产品货号. M22430 CAS No. 1263303-95-2
DHODH-IN-11是来氟米特衍生物，是弱二氢乳清酸脱氢酶（DHODH）抑制剂，pKa为5.03。设计了与来氟米特结构相关的化合物，其中含有呋喃环（化合物14a）。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥786 | 有现货 |
|
| 10MG | ￥1320 | 有现货 |
|
| 25MG | ￥2511 | 有现货 |
|
| 50MG | ￥3750 | 有现货 |
|
| 100MG | ￥5500 | 有现货 |
|
| 500MG | ￥11583 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称DHODH-IN-11
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述DHODH-IN-11是来氟米特衍生物，是弱二氢乳清酸脱氢酶（DHODH）抑制剂，pKa为5.03。设计了与来氟米特结构相关的化合物，其中含有呋喃环（化合物14a）。
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产品描述DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.A compound structurally related to leflunomide was designed, which contained furan ring (compound 14a). Compound 14a undergoes 4 ring cleavage under physiological pH conditions to obtain the corresponding cyanooxime DHODH-IN-11 (compound 14b). DHODH-IN-14 has been analyzed as a DHODH inhibitor; its inefficiency may be due to the unfavorable stereochemistry of the oxime substructure.
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体外实验Designed a compound structurally related to Leflunomide, containing the furazan ring (Compound 14a), is designed. Compound 14a undergo ring 4 scission under physiological pH conditions to afford the corresponding cyano-oximes DHODH-IN-11 (Compound 14b). DHODH-IN-14 has been assayed as a DHODH inhibitor; its low potency is probably due to the unfavourable stereochemistry of the oxime substructure.
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体内实验——
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同义词——
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通路Metabolic Enzyme/Protease
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靶点Dehydrogenase
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受体DHODH
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研究领域——
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适应症——
化学信息
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CAS Number1263303-95-2
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分子量265.27
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分子式C15H11N3O2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 125 mg/mL (471.22 mM)
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SMILESO\N=C(/C#N)C(=O)Nc1ccc(cc1)-c1ccccc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Giorgis M, et al. 1,2,5-Oxadiazole analogues of leflunomide and related compounds. Eur J Med Chem. 2011 Jan;46(1):383-92.
