021-51111890
购物车（）
sales@molnova.cn
DDO-5936
CAS No. 2355377-13-6
DDO-5936 ( —— )
产品货号. M24068 CAS No. 2355377-13-6
DDO-5936 是一种有效且特异性的 HSP90-Cdc37 PPI 抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥988 | 有现货 |
|
| 10MG | ￥1725 | 有现货 |
|
| 25MG | ￥3750 | 有现货 |
|
| 50MG | ￥5532 | 有现货 |
|
| 100MG | ￥7881 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称DDO-5936
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述DDO-5936 是一种有效且特异性的 HSP90-Cdc37 PPI 抑制剂。
-
产品描述DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.
-
体外实验DDO-5936 is a Hsp90-Cdc37 PPI inhibitor with potency and specificity through binding to a critical site on Hsp90 involving Glu47.
-
体内实验DDO-5936 (0~80 mg/kg; p.o.) shows effect at the high dose group.DDO-5936 is well tolerated for the absence of serious weight loss. DDO-5936 high dose groups show that tumor cells in the xenografts decreased significantly. DDO-5936 shows limited oral efficiency. Animal Model:Mice Dosage:0~80 mg/kg Administration:P.o.Result:Showed a moderate effect at the high dose group.
-
同义词——
-
通路Cytoskeleton/Cell Adhesion Molecules
-
靶点HSP
-
受体HSP90
-
研究领域——
-
适应症——
化学信息
-
CAS Number2355377-13-6
-
分子量495.59
-
分子式C25H29N5O4S
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO : 12.5 mg/mL (25.22 mM)
-
SMILESO=C(O)CN(C1=CC=C(NC2=NC(N3CCCC3)=NC=C2)C=C1)S(=O)(C4=C(C)C=C(C)C=C4C)=O
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Discovery and Optimization of Small Molecules Targeting the Protein-Protein Interaction of Heat Shock Protein 90 (Hsp90) and Cell Division Cycle 37 as Orally Active Inhibitors for the Treatment of Colorectal Cancer[J]. Journal of medicinal chemistry, 63(3):1281-1297.
产品手册
