Cltrinin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Citrinin 是一种引起食品污染的真菌毒素，具有不同的毒性作用。Citrinin 通常与另一种肾毒性真菌毒素 Ochratoxin A 一起发现。Citrinin 据报道在体外具有广泛的生物活性，包括抗菌、抗真菌和潜在的抗癌和神经保护作用。

Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity.

Citrinin (1-10 mg/kg; 灌胃; 14 天) 在小鼠体内具有多种免疫调节作用，可能改变免疫系统的正常功能。Citrinin (2 mg/kg; 口服; 3 周) 在 DMBA 诱导的小鼠乳腺癌模型中具有抗肿瘤作用。Animal Model:Female BALB/c mice aged seven weeks oldDosage:1, 5, or 10 mg/kg Administration:Oral gavage (i.g.); 14 days Result:Significantly reduced the populations of F4/80+ cells and CD19+ cells in spleen and MLN. Increased the populations of CD4+, CD8+ and CD4+CD25+Foxp3+ cells in MLN. Increased the populations of CD8+ cells and decreased the populations of CD19+ cells in intra-epithelial, lamina propria and Peyer’s patches lymphocytes. Reduced IgM antibody production in serum. Increased the ratios of Bax/Bcl-2 in the spleen. Up-regulated the expression of Atg5, Beclin-1 and TLR 2 in the spleen.Animal Model:DMBA treated swiss albino female mice aged 6-7 weeks old (25-30 g) Dosage:2 mg/kg Administration:Oral administration (p.o.); 3 weeks Result:Reduced the weight of both breasts, and reduced cell proliferation in the breast. Did not cause necrosis in the cells, the characteristics of the carcinoma such as intraductal calcification, injured tissue, fibrosed with ductal hyperplasia, and histopathological characteristics indicative of preneoplasia still remained. Decreased genotoxic damage, damage index and damage frequency in breast and non-tumor cells induced by DMBA . Did not increase micronuclei or chromosomal bridge formation in hepatocytes of the animals.

Citrinin (0.1-1000 nM; 24 小时) 在谷氨酸处理的大鼠皮层神经元中具有神经保护的作用 (低剂量的情况下)。Citrinin (1- 10 μg/mL; 6 小时) 可诱导免疫细胞晚期凋亡。Citrinin (1- 10 μg/mL; 6 小时) 在新鲜分离的脾细胞中提高了 Bax/Bcl-2 表达水平的比率。Apoptosis Analysis Cell Line:Splenocytes and MLN cells from a SPF mouse ages 7 seven weeks old Concentration:1, 5 and 10 μg/mL Incubation Time:6 h Result:Significantly increased the number of late apoptotic cells, but not in early apoptotic cells.Western Blot Analysis Cell Line:Splenocytes Concentration:1, 5 and 10 μg/mL Incubation Time:6 h Result:Decreased the level of Bcl-2, and the expression of Bax was not affected.

桔霉素

Others

Other Targets

Others

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518-75-2

250.25

C13H14O5

>98% (HPLC)

DMSO : 50 mg/mL (199.80 mM; ultraphonic; )

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(-20℃)

With Ice Pack

≥ 2 years