Cinpanemab ( —— )

产品货号. M36746 CAS No. 2094516-02-4

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HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Cinpanemab
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Cinpanemab (BIIB054) 是一种人源单克隆抗体，可与 α-突触核蛋白 1-10 位残基结合。Cinpanemab 可用于研究帕金森病。
产品描述

Cinpanemab (BIIB054) is a human-derived monoclonal antibody that binds to α-synuclein. Cinpanemab can be used for the research of Parkinson's disease.
体外实验

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体内实验

Animal Model:C57BL/6JRccHsd WT mice, transgenic M83 mice expressing human α-syn A53T, and transgenic bacterial artificial chromosome mice expressing human α-syn A53T were anesthetized and stereotaxically injected with α-syn preformed fibrils (PFFs) into the right forebrain Dosage:30 mg/kg Administration:Intraperitoneal (i.p.) injections 2-3 times prior to α-syn PFF injection and weekly post-injection until time of sacrifice Result:Attenuated the spreading of α-syn pathology, rescued motor impairments, and reduced the loss of dopamine transporter density in dopaminergic terminals in striatum.
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通路

Others
靶点

Other Targets
受体

Others
研究领域

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适应症

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1. Lang AE, et, al. Trial of Cinpanemab in Early Parkinson's Disease. N Engl J Med. 2022 Aug 4;387(5):408-420. ?

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