一种四环抗抑郁药 (TeCA)，充当去甲肾上腺素再摄取抑制剂、α2-肾上腺素受体拮抗剂和血清素受体拮抗剂。

Lesopitron is an anxiolytic with pre- and postsynaptic 5-HT1A agonist activity and is more effective than 5-HT1A agonists in rat social interaction and marmoset anxiety models. lesopitron counteracts benzodiazepine withdrawal-induced anxiety in rodents with low acute toxicity and does not potentiate the effects of alcohol or barbiturates.

AVN-211 (CD-008-0173) 是一种新型、高选择性 5-HT6 受体小分子拮抗剂，Ki 为 2.34 nM。