Ch55

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Ch55 是 HL60 细胞分化的有效诱导剂 (EC50 = 200 nM)，并且与 RAR-α 和 RAR-β 受体具有高亲和力。

Ch55 is an effective inducer of the differentiation of HL60 cells (EC50 = 200 nM) and shows high affinity with RAR-α and RAR-β receptors. Ch55 can be used in studies about cancer.(In Vitro):In rabbit tracheal epithelial cells, Ch55 inhibits type I transglutaminase activity (EC50 = 0.02 nM) and increases cholesterol sulfate levels (EC50 = 0.03 nM) thereby inhibiting squamous cell differentiation. Ch55 inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC50 = 1 nM) and induces cell differentiation of embryonic carcinoma F9 cells and melanoma S91 cells (EC50 = 0.26 and 0.5 nM). Ch55 shows a low affinity for cellular retinoic acid binding protein.

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CH 55 | Ch-55 | 3,5-Di-tert-butylchalcone

Metabolic Enzyme/Protease

Retinoid Receptor

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110368-33-7

364.48

C24H28O3

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (137.18 mM)

CC(C)(C)c1cc(cc(c1)C(C)(C)C)C(=O)\C=C\c1ccc(cc1)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years