Calcimycin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Calcimycin 是一种来自 Chartreusensis 链霉菌的离子载体聚醚羧基抗生素。它结合并跨膜转运钙和其他二价阳离子，解偶联氧化磷酸化，同时抑制大鼠肝线粒体的 ATP 酶。

Calcimycin is an ionophorous, polyether carboxylic antibiotic from Streptomyces chartreusensis.?It binds and transports calcium and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria.?The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.?Calcimycin mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner.Calcimycin (2.5 or 7.5 nM; intrapleurally) induces protein leakage.

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Animal Model:Mice (ICR, 25-30 g)Dosage:2.5 or 7.5 nM Administration:Intrapleurally Result:Two hours after 2.5 nM, or three hours after 7.5 nM, challenge the protein levels in the pleural cavity were equivalent to about a half of their corresponding peak values.

A-23187,Antibiotic A-23187

GPCR/G Protein

Antibacterial

Bacterial|Antifungal|Apoptosis|Autophagy|Antibiotic

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52665-69-7

523.62

C29H37N3O6

>98% (HPLC)

DMSO:47 mg/mL (89.76mM; Need ultrasonic)

[H][C@@]1(O[C@@]2(CC[C@@H](C)[C@@H](Cc3nc4c(C(O)=O)c(NC)ccc4o3)O2)[C@H](C)C[C@H]1C)[C@H](C)C(=O)c1ccc[nH]1

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(-20℃)

With Ice Pack

≥ 2 years