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CYM50260
CAS No. 1355026-60-6
CYM50260 ( —— )
产品货号. M23514 CAS No. 1355026-60-6
CYM50260 是 1-磷酸 4 鞘氨醇受体 (S1P4-R) 的精细激动剂 (EC50: 45 nM)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2908 | 有现货 |
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| 10MG | ￥4350 | 有现货 |
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| 25MG | ￥7031 | 有现货 |
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| 50MG | ￥9639 | 有现货 |
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| 100MG | ￥12879 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称CYM50260
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述CYM50260 是 1-磷酸 4 鞘氨醇受体 (S1P4-R) 的精细激动剂 (EC50: 45 nM)。
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产品描述CYM50260 is an exquisitely agonist of sphingosine-1-phosphate 4 receptor (S1P4-R) (EC50: 45 nM). CYM50260 shows no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R.
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体外实验CYM50260 (Compound 22aa) is a synthetic S1P4-R agonist. CYM50260 is found 3.5-fold more potent than the hit compound (HTS-hit).CYM50260 suppresses the collagen-stimulated platelet aggregation, PDGF-AB secretion and sCD40L release. CYM50260 reduces the release of phosphorylated-HSP27 by collagen as well as the phosphorylation of HSP27.
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体S1P4-R
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研究领域——
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适应症——
化学信息
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CAS Number1355026-60-6
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分子量350.6
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分子式C14H11Cl3FNO2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 125 mg/mL (356.53 mM)
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SMILESFCC1=CC=C(OCCOC2=CC=C(Cl)C=C2Cl)C(Cl)=N1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Guerrero M, et al. Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P?-R) agonists. Bioorg Med Chem Lett. 2012 Jan 1;22(1):537-42.
