CRA-026440

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CRA-026440 是一种有效的广谱 HDAC 抑制剂。作用于 HDAC1，HDAC2，HDAC3，HDAC6，HDAC8 和 HDAC10 的 Ki 分别为 4，14，11，15，7 和 20 nM。CRA-026440 具有抗肿瘤和抗血管生成活性。

CRA-026440 is a potent, broad-spectrum HDAC inhibitor. The Ki values against recombinant HDAC isoenzymes HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10 are 4, 14, 11, 15, 7, and 20 nM respectively. CRA-026440 shows antitumor and antiangiogenic activities. CRA-026440 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Western Blot Analysis Cell Line:HCT116 cells Concentration:0.1 μM, 0.5 μM, 1 μM, 5 μM, 10 μM Incubation Time:18 hours Result:Resulted in the accumulation of both acetylated histones and acetylated tubulin. Induced expression of the cyclin-dependent kinase inhibitor p21Cip1/WAF1.

Animal Model:HCT-116 tumor-bearing nude mice Dosage:100 mg/kg Administration:i.v.; daily; for three consecutive daysResult:Resulted in a statistically significant reduction in tumor growth.

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Cell Cycle/DNA Damage

HDAC

HDAC

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847460-34-8

420.46

C23H24N4O4

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (237.83 mM; 超声助溶 )

O=C(NO)C1=CC=C(C#CCNC(=O)C2=CC=3C=C(OCCN(C)C)C=CC3N2)C=C1

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(-20℃)

With Ice Pack

≥ 2 years