CQ211

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CQ211 是一种有效的、选择性的 RIOK2 抑制剂，Kd 值为 6.1 nM。CQ211 对多种癌细胞均有明显的增殖抑制活性。

CQ211 is a potent and selective RIOK2 inhibitor with a Kd of 6.1 nM. CQ211 exhibits potent proliferation inhibition activity against multiple cancer cell lines.

Western Blot Analysis Cell Line:MKN-1 and HT-29 cells Concentration:0, 0.3, 0.6, 1.2, 2.5, and 5.0 μM Incubation Time:4 h Result:Suppresseed the phosphorylation of mTOR in cancer cells.

Animal Model:Female CB17-SCID mice (6-8 weeks of age) injected wtih MKN-1 cells Dosage:25 mg/kg Administration:Intraperitoneal administration; for 18 consecutive days; once daily Result:Inhibited the tumor progression with tumor growth inhibition (TGI) of 30.9%.

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Others

Other Targets

Others

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2648986-65-4

521.49

C26H22F3N7O2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 12.5 mg/mL (23.97 mM; 超声助溶 (<60°C)

O=C1C2=C(C=3C(N1)=CC=C(C3)C=4C=CC(OC)=NC4)N(N=N2)C5=CC(C(F)(F)F)=C(C=C5)N6CCNCC6

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(-20℃)

With Ice Pack

≥ 2 years