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CLEFMA

CAS No. 1246964-32-8

CLEFMA ( —— )

产品货号. M28778 CAS No. 1246964-32-8

CLEFMA 具有抗增殖活性。 CLEFMA 抑制与 NF-κB 调节的抗炎和抗转移作用相关的肿瘤生长。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥2722 有现货
10MG ¥4026 有现货
25MG ¥6423 有现货
50MG ¥9153 有现货
100MG ¥12312 有现货
500MG ¥24057 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    CLEFMA
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    CLEFMA 具有抗增殖活性。 CLEFMA 抑制与 NF-κB 调节的抗炎和抗转移作用相关的肿瘤生长。
  • 产品描述
    CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.(In Vitro):CLEFMA induces autophagic death in H441 cells. CLEFMA inhibits the viability of H441 and A549 cells, with IC50s of 6.4 and 8.9 μM, respectively. CLEFMA induces apoptosis and reduces the DNA-binding activity of NF-κB in H441 cells in a dose-dependent manner.(In Vivo):Daily intraperitoneal injection of 0.2-0.4 mg/kg CLEFMA for 4 weeks, CLEFMA inhibits tumor growth and FDG uptake in tumor tissue in a xenograft mouse model . In addition, CLEFMA downregulates the expression of anti-apoptotic markers cIAP1, Bcl-xL, Bcl-2, and survivin, and induces the cleavage and expression of the pro-apoptotic protein BID .
  • 体外实验
    CLEFMA (1-100 μM; 24-72 h) has anti-proliferative activity.CLEFMA inhibits the viability of H441 and A549 cells, with IC50s of 6.4 and 8.9 μM, respectively.CLEFMA (5-10 μM; 24 h) induces apoptosis in H441 and A549 cells.CLEFMA (1 and 10 μM; 24 h) induces autophagic death in H441 cells.CLEFMA (1-20 μM) reduces the DNA-binding activity of NF-κB in H441 cells in a dose-dependent manner.Cell Proliferation Assay Cell Line:PANC-1, MiaPaCa-2, PC-3 and H441 cells Concentration:1, 10, 25, 100 μM Incubation Time:24, 48, 72 h Result:Inhibits cells proliferation in a dose-dependent manner.
  • 体内实验
    CLEFMA (0.2-0.4 mg/kg; i.p. daily for 4 weeks) inhibits tumor growth and suppresses the uptake of FDG in tumor tissue in a xenograft mouse model.CLEFMA (0.2-0.4 mg/kg; i.p. daily for 4 weeks) down-regulates the expression of anti-apoptotic markers cIAP1, Bcl-xL, Bcl-2 and survivin, and induces the cleavage of pro-apoptotic protein BID and the expression of pro-apoptotic BAX in tumor tissue. Animal Model:Male athymic nu/nu mice (4 weeks old) are injected H441 cells Dosage:0.2, 0.4 mg/kg Administration: I.p. daily for 4 weeks Result:Inhibited tumor growth up to 96% tumor at dose of 0.4 mg/kg.
  • 同义词
    ——
  • 通路
    Apoptosis
  • 靶点
    NF-κB
  • 受体
    Antibiotic
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    1246964-32-8
  • 分子量
    442.29
  • 分子式
    C23H17Cl2NO4
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    OC(/C=C\C(N(C/C(/C1=O)=C\c(cccc2)c2Cl)C/C1=C\c(cccc1)c1Cl)=O)=O
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.B Nowak-Thompson, et al. Characterization of the pyoluteorin biosynthetic gene cluster of Pseudomonas fluorescens Pf-5. J Bacteriol. 1999 Apr;181(7):2166-74.
产品手册
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