CINPA1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CINPA1 是一种组成型雄甾烷受体 (CAR) 的选择性抑制剂，对于 CAR 介导的转录的 IC50 为 70 nM。 CINPA1可用于CAR功能的研究。

CINPA1 is a selective inhibitor of constitutive androstane receptor (CAR) with an IC50 of 70 nM for CAR-mediated transcription. CINPA1 can be used in studies about CAR function.(In Vitro):CINPA1 is a specific xenobiotic receptor inhibitor and has no cytotoxic effects up to 30 μM. CINPA1 inhibits CAR-mediated gene expression in primary human hepatocytes, where CAR is endogenously expressed and it efficiently inhibits CAR-LBD interaction with the coactivator peptide. CINPA1 (1μM) inhibits CAR-mediated transactivation without activating the pregnane X receptor (PXR) in HepG2 cells. In mammalian two-hybrid assays, CINPA1 increases the corepressor and reduces coactivator interaction with the CAR ligand-binding domain. In chromatin immunoprecipitation assays, CINPA1 disrupts CAR binding to the promoter regions of target genes.

——

——

CINPA 1 | CINPA-1

Others

Other Targets

AMPAR

——

——

102636-74-8

395.503

C23H29N3O3

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (632.13 mM)

CCOC(=O)Nc1ccc2CCc3ccccc3N(C(=O)CN(CC)CC)c2c1

——

(-20℃)

With Ice Pack

≥ 2 years